Georgios Margonis, M.D., Ph.D., a surgical oncology fellow at the Johns Hopkins University School of Medicine, and Matthew Weiss, M.D., surgical director of the Johns Hopkins Liver and Pancreas Cancer Multidisciplinary Clinics, report advances in efforts to improve the treatment and prognosis of colorectal cancers that have spread to the liver.
Below are brief summaries of their recent findings.
1. Improved Preoperative Disease Scoring System
Surgical oncologists at the Johns Hopkins University School of Medicine say they have developed a better scoring system for predicting survival in people with colorectal cancers that have spread to the liver, or CRLM. The ability to more reliably predict outcomes will aid in setting realistic expectations for patients and help physicians tailor treatment plans to maximize patient survival, the surgeons say.
Weiss says his team had been scoring patients using the “gold standard” Fong system, developed in 1999, but many patient outcomes were inconsistent with their prognoses. So the team sought a new approach based on data from 502 patients with CRLM who underwent liver tumor surgery at The Johns Hopkins Hospital from 2000 through 2015.
Statistical analysis identified six separate predictors of poor survival and points were assigned to each based on
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