Today I’ll point out a couple of recently published research results that add to the understanding of Parkinson’s disease and its progression. Parkinson’s disease is comparatively straightforward as neurodegenerative diseases go – which is to say that its biochemistry is still enormously complex in detail, but it hasn’t proven as hard to identify the important aspects as is the case for Alzheimer’s disease. At root, this is a synucleinopathy, a condition caused by the accumulation of α-synuclein deposits. This results in mitochondrial dysfunction and cell death in a small but important population of dopamine-generating neurons connected to motor function, but also a more widespread disruption of normal function in the brain. The challenge in Parkinson’s is less a matter of knowing where to intervene, meaning the targeted removal of α-synuclein, but rather the construction of an effective methodology. You might look at one of the SENS Research Foundation reviews on the topic to get a sense of just how difficult it is to safely clear a specific form of metabolic waste from the brain.
Parkinson’s diseaseneurodegenerative diseasesAlzheimer’s diseasesynucleinopathyα-synucleinmitochondrialdopamine-generating neuronsmotor functionone of the SENS Research Foundation reviews on the topic
Why do only some people develop Parkinson’s disease? In a small number of
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