VIDEO: Video summarizing the main observations resulting from culturing pancreatic tumor cells on the micro-patterned plate. view more
A new cell culture platform allows researchers to observe never-before-seen behaviors of live cancer cells under the microscope, leading to explanations of long-known cancer characteristics.
The easy-to-produce platform developed by Hokkaido University researchers offers cancer cells micro-scale attachment sites that elicit never-before-seen behaviors highly relevant to cancer’s clinical properties. The observation of these behaviors shed light on the mechanisms behind well-known properties of pancreatic cancer, one of the most lethal malignant tumors, and may lead to the identification of new treatment targets.
“Cancer studies so far either use cell cultures in which cancer cells don’t necessarily behave naturally, or tissue samples that don’t allow live observation. So there is a big gap in our knowledge of how cancer cells actually behave,” says Assistant Professor Yukiko Miyatake, who led the study and focuses on cancer development mechanisms. To close this gap, she teamed up with Associate Professor Kaori Kuribayashi-Shigetomi who specializes on micro-nano-scale bio-engineering.
Together they created a new cell culture substrate from a coated glass slide with etched islands of 30μm diameter. For healthy cells, this is just enough space for one
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