IMAGE: PET maximum intensity projections with a constant linear gray scale show multiple liver metastases and subdiaphragmal peritoneal deposits. Tumor and renal uptake persist over time while organs such as spleen,… view more
Credit: GP Nicolas et al., University Hospital Basel, Basel, Switzerland
RESTON, VA – Researchers have shown that a new nuclear medicine procedure could safely and more effectively detect cancerous gastrointestinal and pancreatic neuroendocrine tumors than current methods. The study is featured in the June issue of The Journal of Nuclear Medicine.
Neuroendocrine tumors (NETs) can occur in almost any organ, but they are most commonly observed in the pancreas and gastrointestinal tract. The average time until diagnosis is 3 to 10 years. An estimated 40 to 95 percent of cancerous gastroenteropancreatic NETs (GEP-NETs) have spread to other parts of the body (metastasized) by the time of diagnosis.
Most GEP-NETs express a high density of somatostatin receptor subtype 2 (sst2). These receptors have, therefore, become a prime target for imaging and treating these tumors. Currently, gallium-68 (68Ga)-DOTATOC/-TATE for diagnostic imaging and lutetium-177 (177Lu)-DOTATOC/-TATE for therapy are paired for “theranostic” identification and treatment of NETs.
Preclinical and preliminary clinical evidence indicates that the novel radiolabeled tracer 68Ga-OPS202, an
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