WASHINGTON (Oct. 1, 2018) — Approximately 10-20 percent of diagnosed breast cancers are found to be triple-negative, meaning the breast cancer cells test negative for estrogen and progesterone receptors as well as HER2 receptors, genes that can play a role in the development of breast cancer. Triple-negative breast cancer can be more aggressive and difficult to treat as the cancer cells do not respond to hormonal therapies or therapies that target HER2 receptors.
A new study from the George Washington University (GW) Cancer Center found that nanoparticle-encapsulated doxorubicin is promising in the treatment of triple-negative breast cancer. Doxorubicin is a well-known anthracycline drug class used primarily in combination chemotherapy.
The majority of patients with triple-negative breast cancer receive doses of doxorubicin along with taxane and cyclophosphamide as preoperative chemotherapy. About 25-45 percent of those patients respond to this medication and have excellent long-term prognosis.
“Nanomedicine is a very exciting avenue in modern drug development,” said Adam Friedman, MD, director of the Supportive Oncodermatology Clinic at GW Cancer Center, professor of dermatology at the GW School of Medicine and Health Sciences, and senior author of the study. “Nanotechnology offers many benefits, including the ability to purposefully customize your drug or
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