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IMAGE: An intelligent theranostic agent of molybdenum-based polyoxometalate clusters (denoted as Ox-POM) was developed to respond to the tumor microenvironment for precise photoacoustic imaging of tumor and photothermal therapy under near-infrared… view more 

Credit: D. Ni and W. Cai et al., Department of Radiology, University of Wisconsin-Madison, Madison, Wisc.

PHILADELPHIA – A novel, intelligent theranostic agent for precise tumor diagnosis and therapy has been developed that remains as small molecules while circulating in the bloodstream, can then self-assemble into larger nanostructures in the tumor, and be activated by the tumor microenvironment for therapy guided by photoacoustic imaging. The research was presented at the 2018 Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging (SNMMI).

“Although various types of imaging agents have been developed for photoacoustic (PA) imaging, relatively few imaging agents exhibit high selectivity to the tumor microenvironment for on-demand PA imaging and therapy,” Dalong Ni, PhD, a postdoctoral scholar in the Molecular Imaging and Nanotechnology Laboratory at the University of Wisconsin-Madison (Website: http://mi.wisc.edu; PI: Weibo Cai, PhD), explains. “In this study, an intelligent theranostic agent of molybdenum-based polyoxometalate clusters (denoted as Ox-POM) was designed. These clusters work like an intelligent “nano-robot” in vivo, first searching the

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