Non-small cell lung cancer patients see improved survival with durvalumab

TAMPA, Fla. — Non-small cell lung cancer patients survive longer when their treatment includes durvalumab following platinum-based chemoradiotherapy, according to research led by Moffitt Cancer Center. New clinical trial data published this week in the New England Journal of Medicine show durvalumab improved progression-free survival by 17.2 months compared to placebo.

Durvalumab (Imfinzi®) is an immune checkpoint inhibitor that received United States Food and Drug Administration (FDA) approval in February as a new standard-of-care option for patients with stage 3 non-small cell lung cancer where surgery is not an option and whose disease has not progressed following platinum-based chemoradiotherapy. The therapy, administered intravenously, helps increase T cell activation by blocking a protein called PD-L1 (programmed cell death ligand 1).

Manufactured by AstraZeneca, durvalumab received initial FDA approval in 2017 for locally advanced or metastatic bladder cancer. But Scott Antonia, M.D., Ph.D., chair of the Department of Thoracic Oncology at Moffitt, saw the potential of durvalumab as a treatment option for patients with advanced non-small cell lung cancer. Working with AstraZeneca, he launched the PACIFIC clinical trial, a randomized, double-blind, placebo-controlled international phase 3 trial that spanned 235 investigative sites in 26 countries and enrolled more than 700 patients.



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