IMAGE: This is a photonic Resonator Outcoupler Microscopy (PROM) image that highlights focal adhesions of live dental stem cells. view more
Credit: Yue Zhuo/Brian Cunningham
Focal adhesions are large specialized proteins that are located in the area where a cell membrane meets the extracellular matrix (ECM), a collection of molecules surrounding the cells that provide support and regulate micromechanical signals to the cells. Examining focal adhesions is one of the key elements to understanding how a cell proliferates, differentiates, and migrates–which can help in the treatment of diseases like cancer.
Researchers at the Beckman Institute for Advanced Science and Technology and the Micro and Nanotechnology Laboratory at the University of Illinois have developed a new form of microscopy that allows them to observe the formation and evolution of cell membrane focal adhesions. Their paper, “Quantitative Analysis of Focal Adhesion Dynamics Using Photonic Resonator Outcoupler Microscopy (PROM)” details how the new live cell imaging technique can observe the formation and evolution of cell membrane focal adhesions. It was recently published in Light: Science & Applications.
“This is a new kind of biophysics method used to measure the peak intensity shift (PIS) of the spectra reflected from the biomaterials on a
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