IMAGE: In scans of a 62-yr-old man with Gleason 4+3 PCa treated with radical prostatectomy, with rising PSA level (1.32) and PSA doubling time of 3.7 months, 64CuCl2-PET/CT images revealed 2… view more
Credit: A Piccardo et al., Galliera Hospital, Genoa, Italy
RESTON, Va. – An Italian study featured in the March issue of The Journal of Nuclear Medicine demonstrates that a novel nuclear medicine imaging agent targeting copper accumulation in tumors can detect prostate cancer recurrence early in patients with biochemical relapse (rising prostate-specific antigen [PSA] level).
Copper tends to be more concentrated in tumors, making it a good imaging biomarker. For this study of 50 patients, researchers conducted PET/CT scans comparing the new imaging agent, copper-64 chloride (64CuCl2), with fluorine-18-choline (18F-Choline). Multiparametric magnetic resonance imaging (mpMRI) was also conducted. In addition to calculating the detection rate of each imaging modality, the biodistribution, kinetics of the lesions and radiation dosimetry of 64CuCl2 were evaluated.
“This is the first time this novel agent has been compared with 18F-Choline-PET/CT in a considerable number of prostate cancer patients with biochemical relapse,” explains Arnoldo Piccardo, of E.O. Ospedali Galliera in Genoa, Italy. He points out, “Early detection of prostate cancer relapse may
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