IMAGE: The scheme of the mechanism underlying high-fat diet-induced tumor growth of prostate cancer via IL6-mediated local inflammation. MDSCs, myeloid-derived suppressor cells; STAT3, signal transducer and activator of transcription 3…. view more
Credit: Osaka University
Osaka – Inflammation and evasion of the immune system have been reported to be some of the new hallmarks of cancer. Notably, a high-fat diet (HFD) causes obesity and chronic inflammation, and studies conducted on mice have shown that HFD could be associated with progression and survival of prostate cancer. In human studies, inflammation and immune cells are also linked to prostate cancer.
While much is known about how HFD increases serum proinflammatory cytokines (small proteins that are important in cell signaling), it remains unclear whether tumor progression resulted from these cytokines.
In their latest study, which was reported in Clinical Cancer Research, a team of Osaka University-centered researchers successfully determined the mechanisms of the associations of prostate cancer with inflammation and immune responses.
“We administered an HFD and anti-inflammatory drug celecoxib to a genetically engineered autochthonous mouse model, which corresponds to somatic mutations of human prostate cancer model mice,” explains study lead author Takuji Hayashi. “Tumor growth was evaluated by tumor weight and
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