Organoid profiling identifies treatments for pancreatic cancer
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IMAGE: Organoids grown from 66 pancreatic cancer patients were exposed, one by one, to 5 standard-of-care chemotherapy drugs. After demonstrating that each organoid faithfully replicates the tumor from which it… view more 

Credit: Tuveson Lab, CSHL

Cold Spring Harbor, NY — Patient-derived organoids, hollow spheres of cells cultured from tumors, can quickly and accurately predict how patients with pancreatic cancer respond to a variety of treatments, facilitating a precision-medicine approach to the deadly disease.

That is the conclusion of an international team of researchers led by David Tuveson, Cold Spring Harbor Laboratory (CSHL) Professor and Chief Scientist for The Lustgarten Foundation.

“We’ve been able to identify an approach to prioritize treatment strategies for pancreas cancer patients, with the goal of giving them the best shot at survival and the best shot at a good quality of life,” says Dr. Hervé Tiriac, a researcher in Tuveson’s lab and first author of a paper reporting the findings.

With only 8 percent of patients surviving 5 years beyond their diagnosis, pancreatic cancer is one of the deadliest cancer types. Currently, surgical removal of the cancerous tissue is the only effective treatment, but because the disease progresses so quickly, only 15 percent of

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