Organoids created from patients' bladder cancers could guide treatment
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IMAGE: Organoids created from the bladder cancers of patients mimic the characteristics of each patient’s tumor and may be used in the future to identify the best treatment for each… view more 

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Credit: Columbia University Irving Medical Center

NEW YORK, NY (April 5, 2018)-Columbia University Irving Medical Center (CUIMC) and NewYork-Presbyterian researchers have created patient-specific bladder cancer organoids that mimic many of the characteristics of actual tumors. The use of organoids, tiny 3-D spheres derived from a patient’s own tumor, may be useful in the future to guide treatment of patients.

The study was published today in the online edition of Cell.

In precision medicine, molecular profiling of an individual patient’s tumor is used to identify genetic mutations that drive that individual’s cancer. That knowledge may help physicians select the best drug to fight the cancer, but the analysis does not always predict how a patient will respond to specific therapies.

“The great advantage of organoids is that they are essentially avatars of a patient’s tumor,” said study leader Michael M. Shen, PhD, professor of medicine, genetics & development, urology, and systems biology at Columbia University Vagelos College of Physicians and Surgeons. “Having these personalized laboratory models, which we can make in a matter of

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