Ovarian cancer statistics, 2018
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A new report from the American Cancer Society provides an overview of ovarian cancer occurrence and mortality data. Ovarian Cancer Statistics, 2018 is published early online in CA: A Cancer Journal for Clinicians.

Below are highlights from the report.

In 2018, there will be approximately 22,240 new cases of ovarian cancer diagnosed and 14,070 ovarian cancer deaths in the United States. In the U.S., overall ovarian cancer incidence declined by 29% from 1985 (16.6 per 100,000) to 2014 (11.8 per 100,000), while mortality declined 33% from 1976 (10.0 per 100,000) to 2015 (6.7 per 100,000). Decreases in ovarian cancer incidence has been driven largely by declines in whites that accelerated during the past decade. Racial/ethnic differences in ovarian cancer risk are partially explained by known risk factors. Multiple births, use of oral contraceptives, tubal ligation, and oophorectomy reduce risk, while menopausal hormone use increases risk. However, the source of most of the variation remains unknown. Declines in ovarian cancer mortality are due to reductions in incidence as well as improvements in treatment. The strongest risk factor for ovarian cancer is a family history of breast or ovarian cancer. Mutations in BRCA1 and BRCA2 account for almost 40% of ovarian

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