PCORI Board approves $85 million in new studies on opioids, cancer & other high-burden conditions

WASHINGTON, D.C. — The Patient-Centered Outcomes Research Institute (PCORI) Board of Governors today approved $85 million to fund 16 new studies comparing two or more approaches to improve care and outcomes for a range of conditions and problems that impose high burdens on patients, caregivers and the healthcare system, including unsafe opioid use, cancer, depression and stroke.

The funding total includes $5 million for a University of Washington natural experiment study comparing two approaches to reducing unsafe opioid prescribing in the workers’ compensation system in two state systems, Ohio and Washington. This is the latest project in PCORI’s portfolio of patient-centered comparative clinical effectiveness (CER) studies on substance use disorders and pain management, including 15 of which focus on opioid use.

The Board also approved funding for several other large trials that aim to provide evidence to help patients, clinicians and others choose the most effective therapies or approaches to care. Many involve pragmatic study designs intended to produce results more broadly applicable to a greater variety of patients and care situations and more quickly taken up in routine clinical practice. These awards include:

$15.7 million for a Vanderbilt University Medical Center study comparing the current way stroke care


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