IMAGE: PDX Finder is a free global portal for cancer models. view more
Credit: Spencer Phillips/EMBL-EBI
The European Bioinformatics Institute (EMBL-EBI) and The Jackson Laboratory (JAX) have jointly developed the first open cancer research portal for Patient Derived Xenograft (PDX) models. The freely available PDX Finder is hosted by EMBL-EBI and catalogues PDX models from numerous global repositories. The PDX Finder web portal offers significant potential for collaborative research, as well as time savings for researchers, who now only have to search one central catalogue instead of going through a range of individual and distributed resources.
Researchers create PDX mouse models by implanting tumour fragments from cancer patients into mice with suppressed immune function. By using these models, researchers can get a better idea of how a specific patient would react to a specific drug.
“Preclinical models such as PDX models are very important predictors of the efficacy of anticancer therapies, which currently have a high failure rate in clinical trials,” says Nathalie Conte, PDX Finder Project Lead at EMBL-EBI. “Cancer models are essential for understanding and treating cancer. PDX models are increasingly recognised as clinically relevant because they retain the patient tumour characteristics and imitate a
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