IMAGE: Dr Sylwia Ammoun from Plymouth University Peninsula Schools of Medicine and Dentistry has secured £112,071 from Great Ormond Street Hospital Children’s Charity and Sparks, the medical research charity, to research… view more
Credit: University of Plymouth
The University of Plymouth will be continuing its research into the advancement of neuro-tumour treatments thanks to more than £100,000 from Great Ormond Street Hospital Children’s Charity and Sparks, the medical research charity.
Led by Dr Sylwia Ammoun, Senior Research Fellow in Clinical Neurobiology, together with her co-applicant Professor Oliver Hanemann, the project team will use the funding to further investigate causes of hereditary condition Neurofibromatosis 2 (NF2).
The grant follows the team’s 2017 study, published in leading cancer journal Oncogene, revealing the role of the normal, cellular form of prion protein (PrPC) in the development of NF2-related tumours.
The team found for the first time that PrPC is over-produced in schwannoma (a benign tumour of the tissue that covers nerves) compared with healthy Schwann cells. This overproduction is due to deficiency of a tumour suppressor called Merlin, and strongly contributes to tumour growth and patient prognosis.
Dr Ammoun is part of the University of Plymouth’s Brain Tumour Research Centre of Excellence
Article originally posted at