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IMAGE: Dr Sylwia Ammoun from Plymouth University Peninsula Schools of Medicine and Dentistry has secured £112,071 from Great Ormond Street Hospital Children’s Charity and Sparks, the medical research charity, to research… view more 

Credit: University of Plymouth

The University of Plymouth will be continuing its research into the advancement of neuro-tumour treatments thanks to more than £100,000 from Great Ormond Street Hospital Children’s Charity and Sparks, the medical research charity.

Led by Dr Sylwia Ammoun, Senior Research Fellow in Clinical Neurobiology, together with her co-applicant Professor Oliver Hanemann, the project team will use the funding to further investigate causes of hereditary condition Neurofibromatosis 2 (NF2).

The grant follows the team’s 2017 study, published in leading cancer journal Oncogene, revealing the role of the normal, cellular form of prion protein (PrPC) in the development of NF2-related tumours.

The team found for the first time that PrPC is over-produced in schwannoma (a benign tumour of the tissue that covers nerves) compared with healthy Schwann cells. This overproduction is due to deficiency of a tumour suppressor called Merlin, and strongly contributes to tumour growth and patient prognosis.

Dr Ammoun is part of the University of Plymouth’s Brain Tumour Research Centre of Excellence

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