Researchers at Portland State University have developed methods for measuring levels of free-base nicotine in electronic cigarette (e-cigarette) liquids and vapor, the levels of which are associated with harshness upon inhalation of e-cigarette vapors and tobacco smoke.
The study presents the results of analyses of 11 commercially available flavors of e-cigarette liquids from brands including Element, The Mad Alchemist, Adirondack Vapor, and an industry leader, JUUL. Among the samples tested, the free-base proportions for JUUL’s “Fruit Medley” and “Crème Brulee” flavors were among the lowest. The JUUL fluids are also set apart by their very high total nicotine levels. The JUUL products are low free-base with high total nicotine, the perfect combination for tolerating inhalation of a vape aerosol in which the particles have a high nicotine concentration. As the journal Chemical Research in Toxicology put it in a tweet, “Nicotine state in e-cigarette liquids by NMR. JUUL: high nicotine+low fraction free base = high dose inhalable aerosol.”
According to David Peyton, a Portland State University professor and co-author of the study, in many e-cigarette liquids on the market nicotine is often predominately in its free-base form, which can provide a harsh and unpleasant vaping experience at high nicotine
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