A major new study of more than 140,000 men has identified 63 new genetic variations in the DNA code that increase the risk of prostate cancer.
Researchers devised a new test combining these single letter genetic variants with more than 100 others previously linked to prostate cancer, to predict which men were most at risk of developing the disease during their lifetime.
The test identifies 1 per cent of men who are at highest risk because they have inherited many of these risky variants – and they are nearly six times more likely to develop prostate cancer than the population average.
An international team of researchers led by scientists at The Institute of Cancer Research, London, developed a brand new DNA test to unearth new genetic variants that were particularly hard to find.
Their study is published today (Monday) in the journal Nature Genetics, and was largely funded by the National Cancer Institute in the US, with additional support from the European Research Council, Cancer Research UK and Prostate Cancer UK.
Scientists at The Institute of Cancer Research (ICR) now believe enough is known about prostate cancer genetics to begin assessing whether testing can benefit patients.
They are planning
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