PSMA PET/CT clearly differentiates prostate cancer from benign tissue
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IMAGE: (A and C) Axial PET images. (B and D) Fused PET/CT images. SUVmax of lesion in B was 84.3 and that of lesion in D was 5.7. IRS was 3,… view more 

Credit: Senior author V Prasad, Charité Universitätsmedizin Berlin, Berlin, Germany.

RESTON, Va. – Using nuclear medicine, German researchers have found a way to accurately differentiate cancerous tissue from healthy tissue in prostate cancer patients. The research is highlighted in the February issue of The Journal of Nuclear Medicine.

According to the American Cancer Society, one in nine men will be diagnosed with prostate cancer in his lifetime. Early diagnosis is key to successful treatment.

The new study demonstrates that the maximum standardized uptake value (SUVmax) on Gallium-68 prostate specific membrane antigen (68Ga-PSMA) PET/CT scans correlates with PSMA-expression in primary prostate cancer. By this means, researchers were able to generate an SUVmax cutoff for the differentiation of cancerous and benign prostate tissue.

“To the best of our knowledge, this was the first study to generate a cutoff SUVmax, validated by immunohistochemistry, for separating prostate cancer from normal prostate tissue by 68Ga-PSMA PET/CT images,” explains Vikas Prasad, MD, PhD, of Charité Universitätsmedizin Berlin in Germany. “Our SUVmax cutoff

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