Quartet of NFCR scientists publishes papers in immediate succession

ROCKVILLE, MD – A trio of papers co-authored by four National Foundation for Cancer Research (NFCR) scientists has been published this week in highly-cited and respected journals. Each acknowledges NFCR support as having helped make the works possible.

Rakesh K. Jain, Ph.D., and colleagues detail new knowledge on the interaction of brain cancers, blood vessels and tumor microenvironments, specifically a mechanism by which gliomas resist anti-angiogenesis drugs. The discoveries offer additional insight into why glioblastoma multiforme (GBM), the deadliest form of brain cancer, has to-date remained so notoriously difficult to treat, while too potentially paving the way for future therapeutic approaches that account for these findings.

“I had presented some exciting data on vessel cooption in glioblastoma multiforme at the NFCR scientific symposium in August 2017,” stated Jain, an NFCR fellow. “Our paper based on that work–supported by the Foundation–has now been published in Cancer Cell.”

The article appears in the journal’s issue dated May 14th–Monday.

Another paper specific to gliomas, both of whose corresponding authors, Webster K. Cavenee, Ph.D., and Paul B. Fisher, Ph.D., are closely associated with NFCR, too was published on Monday. Availed online in the Proceedings of the National Academy of Sciences, it identifies a


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