Research discovers how some cancers resist treatment
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IMAGE: This is Lucio Miele, MD, Ph.D., Professor and Chair of Genetics, Director of the Precision Medicine Program at LSU Health New Orleans School of Medicine. view more 

Credit: LSU Health New Orleans

New Orleans, LA – An international team of researchers led by Lucio Miele, MD, PhD, Professor and Chair of Genetics at LSU Health New Orleans School of Medicine, and Justin Stebbing, BM BCh MA, PhD, Professor of Cancer Medicine and Medical Oncology at Imperial College of Medicine in London, has found new genetic mutations that promote the survival of cancer cells. The research also provided a clearer understanding of how some cancer cells are able to resist treatment. The findings are published in PLOS ONE, available here.

“All cancers are caused by genetic damage, mutations to key genes that control the lives of cells,” notes Dr. Miele, who also heads LSU Health New Orleans’ Precision Medicine Program. “Mutant genes that cancers depend upon for survival are called ‘driver’ mutations.”

The researchers tested genes in 44 cancers that no longer responded to therapy. These are not often tested in clinical practice. The tumor types included breast, lung, colorectal, sarcomas, neuroendocrine, gastric and ovarian, among others. They found

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