Researchers Generate Esophagus Organoids from Pluripotent Stem Cells
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25

Sep

2018

25

Sep

2018

Researchers Generate Esophagus Organoids from Pluripotent Stem Cells

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Every tissue requires a different recipe for the production of a functioning structure from the starting point of a few cells: different signals, different environment, different timing. Researchers in the heavily funded tissue engineering community are working their way through the lengthy and costly task of establishing those recipes for every type of organ that might be replaced or repaired. At the same time, there is at present no reliable way to produce the capillary networks needed to support tissues thicker than a few millimeters. The result is an era of organoids, tiny functional sections of organ tissue that are primarily used to accelerate research rather than for the production of therapies. Therapies are nonetheless possible in some cases: sheets of functional tissue can in principle be transplanted onto or into an organ, or even used to generate free-standing tiny assistive organs elsewhere in the body, as demonstrated by the ongoing work at Lygenesis. The set of organoid recipies is expanding and the quality of the end results are improving, with the report here being a representative example of the state of progress in this

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