Researchers look to immune cell shapes to predict how well body will fight lung cancers
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IMAGE: Researchers at Case Western Reserve University have discovered how to quickly and accurately predict which lung cancer patients will benefit from chemotherapy by analyzing how immune cells the body sends… view more 

Credit: Case Western Reserve University

CLEVELAND–Researchers at Case Western Reserve University have discovered how to quickly and accurately predict which lung cancer patients will benefit from chemotherapy by analyzing how immune cells the body sends out to fight the disease are arranged.

The scientists–aided by smart-imaging computers and machine-learning methods–were able to swiftly analyze hundreds of tissue images to not only count cancer-associated immune cells–but identify patterns in how they were arranged.

That breakthrough view can now help determine which patients need chemotherapy or immunotherapy based on computational analysis of routine tissue-slide images obtained either by surgery or biopsy, said Anant Madabhushi, the F. Alex Nason Professor II of biomedical engineering at the Case School of Engineering.

“We believe we’ve made a critical advance to the field with this work,” said Madabhushi, the lead among a dozen authors on a recent paper about the work in the journal Clinical Cancer Research. “Do you need chemo or not?–that’s the direct benefit to the patient and what really

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