CHAPEL HILL – Testicular germ cell cancer, a disease that is rare but growing in incidence in men in the United States, is considered to be among the most curable of solid tumors. Now researchers from the University of North Carolina Lineberger Comprehensive Cancer Center and a consortium of institutions have discovered the genetic and genomic characteristics that define the disease.
In a collaborative effort of The Cancer Genome Atlas Research Network, which is a multi-institution effort to map the genetic and genomic changes in cancer, researchers analyzed 137 testicular germ cell tumors for potential mutations and other molecular changes. They identified molecular features of testicular germ cell cancers that could inform future efforts to improve treatment decisions, and help monitor patients to see if their cancer has come back.
“We now have a better understanding of the molecular characteristics of the histological subtypes of testicular germ cell cancers,” said UNC Lineberger’s Katherine Hoadley, PhD, assistant professor in the UNC School of Medicine Department of Genetics, and the study’s corresponding author. “There is a strong epigenetic component to testicular cancer tumorigenesis.”
Testicular cancer is a rare cancer in the United States, with about 9,310 new cases and 400 deaths occurring each year, according
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