RNA-based therapy cures lung cancer in mouse models

IMAGE: This is Prof. Chandrasekhar Kanduri, Sahlgrenska Academy, Sweden. view more 

Credit: Photo by Johan Wingborg

By turning down the activity of a specific RNA molecule, researchers at Sahlgrenska Academy, Sweden, have cured lung tumors in mice by 40-50 percent. The results, published in Nature Communications, represent the tip of the iceberg in an extensive research project in which 633 new biomarkers for 14 types of cancer have been identified.

A research group led by Chandrasekhar Kanduri, professor of Medical Biochemistry and Cell Biology, studied how tumor development is influenced by long non-coding RNA molecules. These molecules are produced from the part of genome that previously classified as junk DNA, but have been shown to regulate cell division, among other functions.

The evidence supporting the research findings is extensive. The researchers studied 16 different cancer types comprising 6,419 solid tumors, and 701 normal tissue samples which were used as controls. The aim of the research was to find long noncoding RNA molecules that are active during the phase of cell division in which the genetic material is copied.

Using a inhouse developed technology and modern RNA sequencing, the researchers identified 570 long noncoding RNA molecules that are expressed differently


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