Salicylates as an Autophagy Based Approach to Modestly Slow Aging in Nematodes
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20

Sep

2018

20

Sep

2018

Salicylates as an Autophagy Based Approach to Modestly Slow Aging in Nematodes

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A sizable fraction of the many methods demonstrated to slow aging and increase longevity in nematode worms involve increased levels of autophagy. This collection of cellular maintenance and recycling mechanisms become more active following any sort of cellular stress, from heat to toxicity to lack of nutrients. Life span in short lived species is highly plastic in response to environmental circumstances; any minor stress can produce a net benefit. This can make it somewhat challenging to determine whether any particular approach shown to slow aging is in fact acting directly or indirectly via the controlling mechanisms of autophagy, or just stressing cells in some novel way. In the case of salicylates, a category that includes acetylsalicylic acid, better known as aspirin, there is by now enough data to be more certain about what is going on under the hood, however.

It is known that salicylates have beneficial activity on several pathways implicated in inflammation. For example, acetylsalicylic acid (ASA) is known to act as an anti-inflammatory. Interestingly, salicylates and other nonsteroidal anti-inflammatory drugs were also shown to extend lifespan of

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Article originally posted at
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