Sanford Burnham Prebys compound advances into Phase 1 trial for pancreatic cancer
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IMAGE: This is Erkki Ruoslahti, M.D., Ph.D., distinguished professor at SBP and founder, president and CEO of DrugCendR. view more 

Credit: John Gestaldo

LA JOLLA , CALIF. – August 21, 2018 – A compound discovered at Sanford Burnham Prebys Medical Discovery Institute (SBP) has advanced into a Phase 1 trial for metastatic pancreatic cancer. Called CEND-1 (scientifically known as iRGD), the compound was exclusively licensed in 2015 to a private company, DrugCendR Inc. The drug candidate was discovered in the laboratory of Erkki Ruoslahti, M.D., Ph.D., distinguished professor at SBP and founder, president and CEO of DrugCendR.

Solid tumors, such as pancreatic cancer, are difficult to treat. The tumor cells are often surrounded by thick fibrotic walls, making it hard for treatments to get access to the tumor cells. As a result, many solid tumors are also some of the deadliest cancers, including brain, ovarian and pancreatic cancer. Only 8.5 percent of people with pancreatic cancer live more than five years.

CEND-1 overcomes this barrier to allow cancer treatments to penetrate further into the tumor. The compound harnesses a transport pathway that appears to be designed to ferry nutrients to a tissue that is nutrient deficient. The SBP team

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