Scientists use nanoparticles to improve chemotherapy response, boost anti-tumor immunity

IMAGE: (L to R) Mohammad Ali Amini, Ph.D. candidate in the Department of Pharmaceutical Sciences at the Leslie Dan Faculty of Pharmacy and Xiao Yu (Shirley) Wu, senior investigator and professor… view more 

Credit: Steve Southon

U of T scientists use nanoparticles to improve chemotherapy response and boost anti-tumor immunity in breast cancer

Scientists at the University of Toronto’s Leslie Dan Faculty of Pharmacy have seen remarkable success combining tumor modulating nanoparticles with doxorubicin to enhance chemotherapy response in pre-clinical model breast cancer. This combination approach also appears to boost anti-tumor immunity, contributing to the growing excitement surrounding immunotherapy as an avenue to treat cancer. Chemotherapy is a first-line treatment for many cancers; however, the makeup of tumor microenvironments is often a key barrier to the effectiveness of treatment, requiring that patients receive higher doses in order to get the desired result. The adverse effects of repeated high-dose chemotherapy can have significant detrimental effects on a patient’s health, such as damaging healthy tissues and organs, which can themselves be fatal. “The challenge is to find new ways to get better treatment outcomes with lower doses of chemotherapy,” says Xiao Yu (Shirley) Wu, senior investigator and professor at the Leslie


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