Solid tumors targeted in new CAR T-Cell immunotherapy trial

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Credit: Seattle Children’s

SEATTLE – August 7, 2018 – Seattle Children’s has opened a chimeric antigen receptor (CAR) T-cell immunotherapy trial for children and young adults with relapsed or refractory non-central nervous system EGFR-expressing solid tumors. In the phase 1 trial, STRIvE-01, cancer-fighting CAR T cells will target the EGFR protein expressed in many childhood sarcoma, kidney and neuroblastoma tumors.

Solid tumors, excluding those of the brain, make up about 30 percent of all childhood cancers. Sarcoma, a cancer that develops in the bone and soft tissue; kidney malignancies, including Wilms tumor; and neuroblastoma, a tumor that forms in young nerve cells, are the most common types of non-central nervous system solid tumors diagnosed in children. Even as treatment advances have improved childhood cancer survival rates over the last several decades, these solid tumors remain among the most resistant to standard therapy when the cancer relapses or does not respond to initial treatment.

“Despite employing modern treatments that offer more intensive therapy or new drug combinations for children with solid tumors, we’ve been unable


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