IMAGE: Fighting colorectal cancer at UTHealth are Lenard Lichtenberger, Ph.D., (right) and Dexing Fang, Ph.D. view more
Credit: PHOTO CREDIT Rob Cahill, UTHealth
When scientists at The University of Texas Health Science Center at Houston (UTHealth) applied a chemical found in soybeans to a non-steroidal anti-inflammatory drug (NSAID), they increased its anticancer properties and reduced its side effects. Findings of the preclinical study of phosphatidylcholine, also called lecithin, appear in the journal Oncology Letters.
“The results support the potential use of NSAIDs associated with phosphatidylcholine for the prevention and treatment of colorectal cancer,” said Lenard Lichtenberger, Ph.D., the study’s lead investigator and a professor of integrative biology and pharmacology at McGovern Medical School at UTHealth.
The NSAID indomethacin associated with phosphatidylcholine was studied in a head-to-head comparison with three other NSAIDs (one of them aspirin). According to the results, the combination provided superior colorectal cancer protection with less gastrointestinal bleeding. The study was conducted in a mouse model and in laboratory experiments.
Colorectal cancer is the third leading cause of cancer-related death in the United States and is expected to claim 50,630 lives this year.
NSAIDs work by decreasing the production of substances that promote inflammation, pain and fever.
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