The human stress hormone cortisol has been identified by scientists at the University of Kent as a key factor when the immune system fails to prevent leukemia taking hold.
A team led by Dr Vadim Sumbayev, of the University’s Medway School of Pharmacy, found for the first time that blood/bone marrow cancer – acute myeloid leukemia (AML) – cells evade the anti-cancer activity of the human immune system by employing the human hormone cortisol.
The study of the causes of AML – the most severe blood/bone marrow cancer – demonstrated that AML cells employ a unique pathway to progress the disease, using functional systems of the human body to both support their survival and also reduce the anticancer activities of immune cells.
They do this by using cortisol to force the release of a protein, latrophilin 1. This in turn causes the secretion of another protein, galectin-9, which suppresses the body’s natural anti-cancer immune mechanism.
Dr Sumbayev’s team, working with researchers from two German universities and the UK’s Diamond Light Source facility, found that although healthy human white blood cells are not affected by cortisol they become capable of releasing latrophilin 1 when malignant transformation takes place.
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