Given what we know of the relationship between hypertension and dementia, in which increased blood pressure damages the fragile tissues of the brain, causing loss of function over time, it is reasonable to consider that other disruptions of blood flow could have a similar relationship with the onset of dementia in later life. Researchers here…

Checkpoint inhibitor therapies are a demonstrably successful approach to cancer immunotherapy. They suppress a mechanism that normally restrains immune cells from attacking other cells. This mechanism is abused by cancers, alongside a variety of other ways in which the immune system can be subverted or quieted. Any advanced tumor tends to have evolved into a…

Current enthusiasm for the development of means to boost levels of NAD+ in older people is driven in part by research such as the open access paper noted here, in which the authors show a clear decline with age in NAD+ outside cells. Inside cells, NAD+ is an important component in the machinery that allows…

The scientific and medical communities have over recent years lowered the threshold of raised blood pressure that defines hypertension. This has happened due to increasing evidence for even lesser degrees of increased blood pressure to be notably harmful over the long term. There is apparently no such thing as a safe rise in blood pressure…

09 Nov 2018 09 Nov 2018 Fibroblasts in Old Skin Lose their Functional Identity Loading… Loading… Researchers here describe the character of fibroblasts in old skin as a loss of characteristic function and identity. The fibroblasts begin to take on aspects of other cell types, and thus the character of skin changes for the worse….

In flies, the declining state of the intestine is a critical aspect of aging, the strongest determinant of mortality. This central position of the intestine in aging is not the case in mammals, but loss of integrity of the intestinal wall is still a major driver of chronic inflammation. That inflammation in turn accelerates progression…

Lower protein intake is suspected of being a contributing cause of a number of age-related conditions, such as sarcopenia, the loss of muscle mass and strength. Researchers here find an association between lower protein intake and a faster pace of decline with age, but it is easy to argue over the direction of causation. After…

The business community includes many supporting organizations that host conferences, cultivate professional networks, and analyze markets and businesses. The biotechnology industry is waking up to the potential of treating aging as a medical condition, particularly now that a sizable amount of venture funding is flowing to the development of the first rejuvenation therapies worthy of…

The hallmarks of aging paper described a categorization of aging into discrete forms of damage and change, strongly influenced by more than a decade of work to popularize the SENS view of aging as a catalog of forms of molecular damage. The hallmarks are distinct from the SENS categorization, incorporating a number of items that…

Modern hunter-gatherer societies are located in the poorer parts of the world, and thus still face challenges in the control of infectious disease. When it comes to age-related disease they can be notably better off than those of us in the typist-shopper societies of wealthier regions, however. This, I would say, has less to do…

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