At its most dramatic, oxidative stress can rend DNA in two and predispose cells to mutations that ultimately result in cancer. But the less bombastic effects of reactive oxygen molecules are no less damaging, as they likely play a central role in the world’s number one killer, vascular disease, causing stroke and heart attack among

It looks like those clumps of tau protein that form inside the neurons of Alzheimer’s brains may actually be protective, and the real damage might instead come from tau oligomers. If you take a major flesh wound to the emergency room for treatment, they probably won’t slather a metformin cream on you… but maybe they…

(Part I of II.) Researchers at UNC Chapel Hill had an interesting mission: first, transform scar tissue (like the kind that forms after heart attacks) into ordinary cardiac muscle. Researchers at UNC Chapel Hill Of course, that wasn’t the interesting part. We’ve been able to transform cells of one type into cells of another, completely…

Last week we heard the theoretical side of Dr. Michael Fossel’s mission to bring aging to its knees, and why his chosen point of attack was on the grand orchestrator of the body’s repair processes. This week he goes into the practical details: how does he plan to lengthen telomeres? What can we treat with…

The Hippo pathway controls cellular regeneration, so why not modify it to heal the heart after the scarring caused by a heart attack? Six weeks later, mouse hearts were good as new. modify it Cytomegalovirus (a herpes virus) infects over 90% of humans, often silently, but this mostly harmless little viral companion takes up far…

“All of this time I had been thinking about telomere maintenance in terms of the minuscule cellular molecular structures that they are, and the genes that control telomeres. When Elissa posed her question, however, I suddenly saw telomeres in a whole new light. I saw how they impacted the lives of real people.” More of…

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