For the most part, we know how to mitigate the chronic diseases that plague people in their older years–eat healthily from early on, and get plenty of exercise. But this knowledge hasn’t translated into better health for society at large, and medical systems all around the world are straining increasingly under the weight of aging…

(Continued from part I) Most people who’ve meet cancer on the battlefield of treatment, doctors or patients, come away with the impression of a robust and formidable foe that can only be defeated with the most terrible weapons. But this impression is somewhat misleading. The cancers that come to our attention are selected for being…

Last week when we heard from Dr. Ristow, he turned the outdated notion of the “free radical theory of aging” on its head, and demonstrated that antioxidants like vitamin A and vitamin C aren’t all they’re cracked up to be. But if those supplements can’t help us, what can? Perhaps, says Ristow, the answer can…

Dr. Michael Ristow, a professor of energy metabolism at ETH Zurich, bases much of his research into aging on a premise that many of us will find surprising: the free radicals that our cells produce while making energy are not only not harmful, but can even slow the body’s aging down. But while that might…

Since the world of Alzheimer’s therapeutics hasn’t seen much practical benefit from targeting harmful proteins like amyloid-beta, maybe other approaches like targeting dysfunctional mitochondria are worth exploring in more depth. Apparently, improving mitochondrial function can decrease plaque burden and improve cognition in a mouse model. Why do cancer survivors have shorter lifespans than the rest

TIL that one of my favorite condiments, Liquid Smoke, is basically just like eating advanced glycation end products (AGEs). That and other gems can be found in Buck Institute researcher Pankaj Kapahi’s seminar on metabolism and aging, here. here Our very own James Peyer talks about the trajectory of the anti-aging field at TEDxStuttgart. Also see Fight…

The Hippo pathway controls cellular regeneration, so why not modify it to heal the heart after the scarring caused by a heart attack? Six weeks later, mouse hearts were good as new. modify it Cytomegalovirus (a herpes virus) infects over 90% of humans, often silently, but this mostly harmless little viral companion takes up far…

“All of this time I had been thinking about telomere maintenance in terms of the minuscule cellular molecular structures that they are, and the genes that control telomeres. When Elissa posed her question, however, I suddenly saw telomeres in a whole new light. I saw how they impacted the lives of real people.” More of…

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