The researchers bound the kind of siRNA found in Huntington’s disease with a complementary strand from another degenerative disorder, myotonic dystrophy, to create a hybrid duplex, then put this inside nanoparticles that were quickly gobbled up by cancer cells in culture. All varieties of cancer tested–ovarian, lung, liver, melanoma, and several more–stopped growing within a…

What good is a longer life if you have to spend half of it keeping up with the news? Ditch those endlessly scrolling feeds, and instead join us every other week for a concentrated dose of the most exciting developments in the field of geroscience. Here’s the recap: Naked mole rats really do age better,…

It’s looking increasingly likely that our little bacterial buddies have a major influence on neurodegenerative disease, from producing extra amyloid, to regulating inflammation, to generating free radicals. In mouse models of Alzheimer’s disease, a protein complex that forms part of the nervous system’s innate immune system binds to toxic amyloid-beta, promoting the formation of plaques.

Part of a series on the Hallmarks of Aging. Proteins don’t do everything in your body, but it’s fair to say they control everything. What they don’t do directly, they catalyze. Proteins handle everything from copying DNA, to stabilizing a neuron’s physical structure, to turning starch into sugar. If something goes wrong in the body,

Long before the usual physiological signs, the withering of neurons and the gradual atrophy of the brain, that tip doctors off to the presence of a neurodegenerative disease, there’s already something different about their patients’ brain cells. Action potentials flash across a long, thin arm protruding from the cell body in a healthy neuron, and…

It’s been known for ages that individuals with two ApoE4 alleles were virtually destined to develop Alzheimer’s, but its link with the hallmark Alzheimer’s protein amyloid-beta was obscure, and it wasn’t clear what ApoE really did in the brain. Now researchers think that the culprit is the inflammatory response it triggers in the presence of…

Laboratories studying the biology of aging are a menagerie of creatures great and small. From unicellular yeast and nematodes, all the way up to primates and even the faithful old Canis familiaris, animal models have opened up the aging process to our inspection in ways that human subjects wouldn’t have been able to match. It’s…

Just like a well-folded sheet of paper, a tightly coiled segment of DNA doesn’t have much chance of being read. Our cells use this to their advantage, unspooling the genes they need at the moment with negatively charged acetyl groups, and using ‘eraser’ enzymes that remove these groups to roll up the instructions they don’t…

Many people think of sleep almost as if it were a state of suspended animation, like turning off a computer so that it can cool down. But while your conscious mind and certain activities are dormant, much of your body is hard at work repairing damage, replenishing energy stores, and clearing away waste, in addition…

Lessons from 300 year old tubeworms: Lessons The low 0.67% mortality rate … supports longevity theory, which states that in the absence of extrinsic mortality threats, natural selection will select for individuals that senesce slower and reproduce continually into their old age. The low 0.67% mortality rate … supports longevity theory, which states that in…

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