Alexandria, VA, USA – The International and American Associations for Dental Research (IADR/AADR) have published a special issue in the Journal of Dental Research (JDR) on head and neck cancer. Dr. Jacques E. Nör, University of Michigan, Ann Arbor, USA and Dr. J. Silvio Gutkind, University of California, San Diego, USA, served as the guest editors of this special issue.
Head and neck cancer encompasses a large and diverse group of tumors with complex etiology and pathobiology that is typically resistant to therapy, particularly when diagnosed in advanced stages. The most common of these tumors are head and neck squamous cell carcinomas (HNSCC), which are diagnosed in about half million people and result in a quarter million deaths every year worldwide. Unfortunately, the overall 5-year survival of HNSCC patients has remained low at about 50-60% for the last 3-4 decades. The lack of more effective therapies has been attributed to late diagnosis and to the intrinsic resistance of HNSCC cells to existing treatment modalities.
In recent years, the prospect of developing safe and efficient therapies for HNSCC has improved by a deeper understanding of the precise mechanisms underlying the biology of these tumors. This special issue of the Journal
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