IMAGE: This is an artistic interpretation of the ‘two-headed’ arrow UVA is developing to destroy ovarian cancer. view more
Credit: Image by Anita Pagliazzo, as conceived and designed by Jogender Tushir-Singh.
A University of Virginia School of Medicine researcher is developing a two-fisted, antibody-based approach to destroy deadly ovarian cancer — an approach he believes could also be modified to kill breast, prostate and other solid tumors.
The dual-pronged approach being developed by Jogender Tushir-Singh, PhD, aims to overcome obstacles that have undermined otherwise promising immune therapies for ovarian cancer, the deadliest gynecological disease. If the approach proves successful, it may even rescue some failed therapies, allowing doctors to move them from the scrap heap to the clinic, where they could benefit patients.
“There are a lot of efforts in terms of cancer immune therapy, but the success of these are really limited in solid tumors,” said Tushir-Singh, of UVA’s Department of Biochemistry and Molecular Genetics and the UVA Cancer Center. “I strongly believe, and with my own experience while working in the pharmaceutical industry, that this advancement will allow us to rescue and give a second lease on life to a lot of antibodies that have failed in
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